Stem Cell-Based Therapies in Chagasic Cardiomyopathy
نویسندگان
چکیده
منابع مشابه
Stem Cell-Based Therapies in Chagasic Cardiomyopathy
Chagas disease is caused by Trypanosoma cruzi and can lead to a dilated cardiomyopathy decades after the prime infection by the parasite. As with other dilated cardiomyopathies, conventional pharmacologic therapies are not always effective and as heart failure progresses patients need heart transplantation. Therefore alternative therapies are highly desirable and cell-based therapies have been ...
متن کاملCell based therapies in retinal diseases
Background Degenerative retinal diseases, including age related macular degeneration, glaucoma, and hereditary retinal dystrophies are major causes of blindness. The principal defect in these diseases is cell loss which is amenable to both cell based neuroprotective and neuroregenerative therapies. To briefly review the lines of research and potential candidates for cell based therapies among ...
متن کاملNovel Cell-Based Therapies in Hepatic Disorders
In the recent decade, liver diseases with high mortality rate have became one of the major health problems worldwide. Liver transplantation is the most effective and the standard treatment for decompensated liver disease, but, shortage of available organs and inaccuracy in modeling of the liver diseases are the most limiting issues in treatment. Regenerative medicine and cell based therapy str...
متن کاملChagasic Cardiomyopathy
Infection of beagles with an opossum-derived strain of Trypanosoma cruzi (Tc-O) results in features of early and chronic chagasic cardiomyopathy, that is, increases in PR interval, atrioventricular block, and frequent ventricular premature contractions, ventricular tachycardia, and decreased left ventricular ejection fraction. These signs are not observed in animals infected with a canine strai...
متن کاملMitochondrial disorders in chagasic cardiomyopathy.
The mitochondria play a complex multi-factorial role in the cell. Along with their primary role in energy (ATP) production, mitochondria generate reactive oxygen species (ROS) that directly or indirectly affect several cellular functions. In this article, I review the molecular, structural and functional mitochondrial abnormalities reported in chagasic cardiomyopathy. I highlight current inform...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BioMed Research International
سال: 2015
ISSN: 2314-6133,2314-6141
DOI: 10.1155/2015/436314